You should not use Upneeq if:
you are allergic to its ingredients
high or low blood pressure;
heart problems;
Sjögren’s syndrome;
blood circulation problems;
glaucoma; or
an eye injury or infection.

Follow all directions on your medicine label and package. Tell each of your healthcare providers
about all your medical conditions, allergies, and all medicines you use.
Related/similar drugs
oxymetazoline ophthalmic
Pregnant or Breastfeeding

Always follow directions on the medicine label about giving this medicine to a child. Do not give this
medicine to a child younger than 6 years old without medical adviceHow should I use Upneeq?
Use exactly as directed on the label, or as prescribed by your doctor. Using this medicine too long
or too often may worsen your symptoms and cause damage to the blood vessels in your eyes.
Do not use while wearing soft contact lenses. A preservative in this medicine could permanently
stain the lenses. Use the medicine at least 15 minutes before inserting your contact lenses.
Wash your hands before using eye medication.
Shake the eye drops well just before each use.
To apply the eye drops: Tilt your head back slightly and pull down your lower eyelid to create a
small pocket. Hold the dropper above the eye and squeeze a drop into this pocket. Close your
eyes for 1 or 2 minutes.?
Use only the number of drops recommended.
Do not touch the tip of the eye dropper or place it directly on your eye. A contaminated dropper can
infect your eye, which could lead to serious vision problems.
Call your doctor if your symptoms do not improve after 3 days of treatment.
Store this medicine in an upright position at room temperature. Do not freeze.
Keep this medicine out of the reach of children. Certain eye medications can cause serious
medical problems in a young child who accidentally sucks on or swallows medicine from the eye
dropper.
Each single-use container is for one use only. Throw it away after one use, even if there is still
medicine left inside.
What happens if I miss a dose?
Since Upneeq is sometimes used when needed, you may not be on a dosing schedule. Skip any
missed dose if it’s almost time for your next dose. Do not use two doses at one time.
What happens if I overdose?
An overdose of Upneeq is not expected to be dangerous. Seek emergency medical attention or
call the Poison Help line at 1-800-222-1222 if anyone has accidentally swallowed the medicine.
What should I avoid while using oxymetazoline ophthalmic?
Do not use other eye medications unless your doctor tells you to.
Upneeq side effects
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing;
swelling of your face, lips, tongue, or throat.
Upneeq may cause serious side effects. Stop using Upneeq and call your doctor at once if you
havesigns of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or
throat.
Upneeq may cause serious side effects. Stop using Upneeq and call your doctor at once if you
have:
a light-headed feeling, like you might pass out;
ongoing or worsening eye redness;
eye pain; or
changes in your vision.
Common side effects of Upneeq may include:
mild burning or stinging of the eye;
blurred vision, watery eyes; or
mild headache, dizziness, nervousness.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice
about side effects. You may report side effects to FDA at 1-800-FDA-1088
What other drugs will affect Upneeq?
Ask a doctor or pharmacist before using oxymetazoline with any other medications, especially:
heart or blood pressure medicine;
a beta blocker–atenolol, carvedilol, labetalol, metoprolol, nadolol, nebivolol, propranolol, sotalol,
and others; or
an MAO inhibitor–isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline,
selegiline, tranylcypromine, and others.
This list is not complete. Other drugs may affect oxymetazoline, including prescription and
over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are
listed here.